2009年12月12日
キサントフモールは前立腺ガン予防に役立ちえる！
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ホップ化合物・キサントフモールはテストステロン作用を阻止する！
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ビールの苦味付けに使用されるホップ由来化合物・キサントフモールはテストステロン受容体の核内移行を阻止し、テストステロン誘発性の前立腺特異抗原（PSA）分泌やその他のテストステロン依存的作用を阻止する効果があると分かりました。
キサトフモールは前立腺癌予防に役立つでしょう。
今回の研究結果はAmerican Association for Cancer Research Frontiers in Cancer Prevention Research Conferenceで発表されました。
（英文解説）
Beer 'may prevent prostate cancer'
Men now have another excuse to go down the pub thanks to new research suggesting that a compound in beer may prevent prostate cancer.
Tests showed that the ingredient, xanthohumol, blocked a biological pathway that allows prostate cancer to be fuelled by the male hormone testosterone.
The disease is commonly treated with drugs that act in a similar way.
Xanthohumol is a powerful antioxidant derived from hops. It belongs to a family of chemicals called flavonoids found in many fruits, vegetables and spices that are known to have anti-cancer properties.
Previous studies have already suggested that xanthohumol may block the female hormone oestrogen's ability to stimulate breast cancer. Scientists now believe it may have a similar effect in men.
In laboratory tests, the compound blocked the molecular "switch" that allows testosterone to trigger changes in prostate cells that may lead to cancer.
Study leader Dr Clarissa Gerhausa, from the German Cancer Research Centre in Heidelberg, said: "We hope that one day we can demonstrate that xanthohumol prevents prostate cancer development, first in animal models and then in humans, but we are just at the beginning."
Further research involving rats showed that zanthohumol reduced the effects of hormone signalling in prostate tissue.
Details of the study were presented at the Frontiers in Cancer Prevention Research Conference in Houston, Texas, US.
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